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One in four female deaths in the United States is due to heart disease. Kinesiology Assistant Professor Michael Nelson hopes to reduce that number by studying the root causes of coronary microvascular dysfunction, a condition that damages tiny coronary arteries in women.
"Our previous research has shown that the heart muscle doesn't relax properly in these women, and that they are prone to developing heart failure. But we don't understand why," says Dr. Nelson, who won a four-year grant from the American Heart Association for his study. "Our hypothesis is that the impaired relaxation of the heart is directly related to coronary microvascular dysfunction and contributes to the progression of heart failure."
He and his team will use MRI techniques to test their theory on 30 subjects. Half of the patients will have the condition; the other half will be age- and gender-matched controls. Participants also will be given a phosphodiesterase type 5 inhibitor—a drug that is known to improve microvascular blood flow—to see if it can alleviate the disorder and restore normal heart function. Area cardiologists will prescribe the medication.
Anne Bavier, dean of the College of Nursing and Health Innovation, believes Nelson's research could prove to be a potent weapon in the war against heart disease.
"Heart disease is the leading cause of death for women in the United States," she says. "The outcome of this study could go a long way toward saving the lives of hundreds of thousands of women and improving the quality of life for millions of others."
Illustration by Henry Campbell
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